Umi Budi Rahayu
Universitas Muhammadiyah Surakarta, Surakarta Indonesia
Title: Prediction of Motor Outcomes After Physiotherapy with Neurobiological Marker in Ischemic Stroke Patients
Biography
Biography: Umi Budi Rahayu
Abstract
The motor output is one of the main targets of rehabilitation in stroke patients. Post-stroke physiotherapy as rehabilitation is associated with the process of plasticity due to neurobiological activity, including the activity of the Brain-Derived Neurotrophic Factor (BDNF) expression. Lack of studies had been undertaken to explore motor improvement associated with BDNF protein activity. This paper aimed to predict motor outcome in the form of balance and functional ability post-stroke with BDNF markers after being given physiotherapy. The Study involving 32 respondents conducted in 3 Indonesia hospitals for 7 days after being diagnosed with ischemic stroke on CTScan in the inclusion criteria. Measurements of pre-posttest of BDNF expression using human BDNF immunoassay marker, then motor outcome related balance using Berg Balance Scale and functional abilities using Barthel Index. Prediction of the motor outcome was done by calculating the absolute improvement in a clinical score that be expressed as a proportion or percentage of the available improvement in that score. There was absolute improvement of motor outcome associated with balance and functional ability after physiotherapy in ischemic stroke patients. It also shows an increased in BDNF expression by BDNF marker. The increase in BDNF expression was 48.52% followed by an absolute improvement in balance by 62.47% and functional ability by 69.87% after 7 days’ post stroke. Neurobiological marker using BDNF marker can help to predict motor outcome both balance and functional ability after physiotherapy in stroke patients.